Rigidity of the Outer Shell Predicted by a Protein Intrinsic Disorder Model Sheds Light on the COVID-19 (Wuhan-2019-nCoV) Infectivity
Identifieur interne : 000384 ( Main/Exploration ); précédent : 000383; suivant : 000385Rigidity of the Outer Shell Predicted by a Protein Intrinsic Disorder Model Sheds Light on the COVID-19 (Wuhan-2019-nCoV) Infectivity
Auteurs : Gerard Kian-Meng Goh [Singapour] ; A. Keith Dunker ; James A. Foster [États-Unis] ; Vladimir N. Uversky [États-Unis, Russie]Source :
- Biomolecules [ 2218-273X ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Protéines virales.
- métabolisme : Protéines virales.
- épidémiologie : Infections à coronavirus, Pneumopathie virale.
- Animaux, Humains, Pandémies, Pénétration virale.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Viral Proteins.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- chemical , metabolism : Viral Proteins.
- physiology : Betacoronavirus.
- transmission : Coronavirus Infections, Pneumonia, Viral.
- Animals, Humans, Pandemics, Virus Internalization.
Abstract
The world is currently witnessing an outbreak of a new coronavirus spreading quickly across China and affecting at least 24 other countries. With almost 65,000 infected, a worldwide death toll of at least 1370 (as of 14 February 2020), and with the potential to affect up to two-thirds of the world population, COVID-19 is considered by the World Health Organization (WHO) to be a global health emergency. The speed of spread and infectivity of COVID-19 (also known as Wuhan-2019-nCoV) are dramatically exceeding those of the Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV). In fact, since September 2012, the WHO has been notified of 2494 laboratory-confirmed cases of infection with MERS-CoV, whereas the 2002–2003 epidemic of SARS affected 26 countries and resulted in more than 8000 cases. Therefore, although SARS, MERS, and COVID-19 are all the result of coronaviral infections, the causes of the coronaviruses differ dramatically in their transmissibility. It is likely that these differences in infectivity of coronaviruses can be attributed to the differences in the rigidity of their shells which can be evaluated using computational tools for predicting intrinsic disorder predisposition of the corresponding viral proteins.
Url:
DOI: 10.3390/biom10020331
PubMed: 32092911
PubMed Central: 7072294
Affiliations:
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Keith" last="Dunker">A. Keith Dunker</name><affiliation><nlm:aff id="af2-biomolecules-10-00331">Center for Computational Biology, Indiana and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA;<email>kedunker@iupui.edu</email></nlm:aff></affiliation></author><author><name sortKey="Foster, James A" sort="Foster, James A" uniqKey="Foster J" first="James A." last="Foster">James A. Foster</name><affiliation><nlm:aff id="af3-biomolecules-10-00331">Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA;<email>foster@uidaho.edu</email></nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af4-biomolecules-10-00331">Institute for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow, ID 83844, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow, ID 83844</wicri:regionArea><placeName><region type="state">Idaho</region></placeName></affiliation></author><author><name sortKey="Uversky, Vladimir N" sort="Uversky, Vladimir N" uniqKey="Uversky V" first="Vladimir N." last="Uversky">Vladimir N. Uversky</name><affiliation wicri:level="4"><nlm:aff id="af5-biomolecules-10-00331">Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612</wicri:regionArea><placeName><region type="state">Floride</region><settlement type="city">Tampa</settlement></placeName><orgName type="university">Université de Floride du Sud</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="af6-biomolecules-10-00331">Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center ‘Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences’, Moscow region, 142290 Pushchino, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center ‘Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences’, Moscow region, 142290 Pushchino</wicri:regionArea><wicri:noRegion>142290 Pushchino</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biomolecules</title><idno type="eISSN">2218-273X</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Betacoronavirus (physiology)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (transmission)</term><term>Humans</term><term>Pandemics</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (transmission)</term><term>Viral Proteins (genetics)</term><term>Viral Proteins (metabolism)</term><term>Virus Internalization</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Infections à coronavirus (transmission)</term><term>Infections à coronavirus (épidémiologie)</term><term>Pandémies</term><term>Pneumopathie virale (transmission)</term><term>Pneumopathie virale (épidémiologie)</term><term>Protéines virales (génétique)</term><term>Protéines virales (métabolisme)</term><term>Pénétration virale</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines virales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Pandemics</term><term>Virus Internalization</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Pandémies</term><term>Pénétration virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The world is currently witnessing an outbreak of a new coronavirus spreading quickly across China and affecting at least 24 other countries. With almost 65,000 infected, a worldwide death toll of at least 1370 (as of 14 February 2020), and with the potential to affect up to two-thirds of the world population, COVID-19 is considered by the World Health Organization (WHO) to be a global health emergency. The speed of spread and infectivity of COVID-19 (also known as Wuhan-2019-nCoV) are dramatically exceeding those of the Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV). In fact, since September 2012, the WHO has been notified of 2494 laboratory-confirmed cases of infection with MERS-CoV, whereas the 2002–2003 epidemic of SARS affected 26 countries and resulted in more than 8000 cases. Therefore, although SARS, MERS, and COVID-19 are all the result of coronaviral infections, the causes of the coronaviruses differ dramatically in their transmissibility. It is likely that these differences in infectivity of coronaviruses can be attributed to the differences in the rigidity of their shells which can be evaluated using computational tools for predicting intrinsic disorder predisposition of the corresponding viral proteins.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Goh, G K" uniqKey="Goh G">G.K. Goh</name></author><author><name sortKey="Dunker, A K" uniqKey="Dunker A">A.K. Dunker</name></author><author><name sortKey="Uversky, V N" uniqKey="Uversky V">V.N. Uversky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goh, G K" uniqKey="Goh G">G.K. Goh</name></author><author><name sortKey="Dunker, A K" uniqKey="Dunker A">A.K. Dunker</name></author><author><name sortKey="Foster, J A" uniqKey="Foster J">J.A. Foster</name></author><author><name sortKey="Uversky, V N" uniqKey="Uversky V">V.N. Uversky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goh, G K" uniqKey="Goh G">G.K. Goh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goh, G K" uniqKey="Goh G">G.K. Goh</name></author><author><name sortKey="Dunker, A K" uniqKey="Dunker A">A.K. Dunker</name></author><author><name sortKey="Uversky, V N" uniqKey="Uversky V">V.N. Uversky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goh, G K" uniqKey="Goh G">G.K. Goh</name></author><author><name sortKey="Dunker, A K" uniqKey="Dunker A">A.K. Dunker</name></author><author><name sortKey="Uversky, V N" uniqKey="Uversky V">V.N. Uversky</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Goh, G K" uniqKey="Goh G">G.K. Goh</name></author><author><name sortKey="Dunker, A K" uniqKey="Dunker A">A.K. Dunker</name></author><author><name sortKey="Foster, J A" uniqKey="Foster J">J.A. Foster</name></author><author><name sortKey="Uversky, V N" uniqKey="Uversky V">V.N. Uversky</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Russie</li><li>Singapour</li><li>États-Unis</li></country><region><li>Floride</li><li>Idaho</li></region><settlement><li>Tampa</li></settlement><orgName><li>Université de Floride du Sud</li></orgName></list><tree><noCountry><name sortKey="Dunker, A Keith" sort="Dunker, A Keith" uniqKey="Dunker A" first="A. Keith" last="Dunker">A. Keith Dunker</name></noCountry><country name="Singapour"><noRegion><name sortKey="Goh, Gerard Kian Meng" sort="Goh, Gerard Kian Meng" uniqKey="Goh G" first="Gerard Kian-Meng" last="Goh">Gerard Kian-Meng Goh</name></noRegion></country><country name="États-Unis"><region name="Idaho"><name sortKey="Foster, James A" sort="Foster, James A" uniqKey="Foster J" first="James A." last="Foster">James A. Foster</name></region><name sortKey="Uversky, Vladimir N" sort="Uversky, Vladimir N" uniqKey="Uversky V" first="Vladimir N." last="Uversky">Vladimir N. Uversky</name></country><country name="Russie"><noRegion><name sortKey="Uversky, Vladimir N" sort="Uversky, Vladimir N" uniqKey="Uversky V" first="Vladimir N." last="Uversky">Vladimir N. Uversky</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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